A report in ACS Applied Materials & Interfaces demonstrates the use of green tea compounds in improving cancer tumor imaging in mice.
“Enhanced In Vitro and In Vivo Cellular Imaging with Green Tea Coated Water-Soluble Iron Oxide Nanocrystals” was published in the journal in March 2015.
Nanoparticles, particularly iron oxide, have been shown to improve imaging in biomedical settings. But nanoparticles are not always cooperative. They like to bunch together and it can be a challenge to ensure that they spread throughout the entire body.
Researcher Sanjay Mathur and his team thought using natural substances in conjunction with the nanoparticles could stop this clumping behavior. In the lab they developed water-soluble iron oxide nanocrystals that were coated with EGCT and epicatechin. They found that these altered nanoparticles (which they referred to as SPIONs, superparamagnetic iron oxide nanocrystals) made their way to the tumor cells and improved visibility and contrast.
The study was funded in part by the University of Cologne and the EU Project Nanommune.
Source: American Chemical Society