The American Cancer Society projects that 233,000 men will be diagnosed with prostate cancer in 2014. It is the most prevalent type of cancer in men after skin cancer, affecting one in seven men in the course of their lives. Given tea’s reputation as a healthful beverage with powerful antioxidants, it is not surprising that researchers would be considering the potential impact of green tea on prostate cancer.
A new report published by “Metabolomics” in May 2014 found that epigallocatechin-3-gallate (EGCG), a catechin in green tea, may affect the work of one of the enzymes that powers cancer metabolism.
In many cancer types, the enzyme Lactate dehydrogenase A (LDHA) is present in elevated amounts. LDHA affects the way that the chemical compound pyruvate is processed. Pyruvate is produced in glycolysis and would typically continue to metabolize, giving the body’s cells energy. When cells lack the oxygen they need, pyruvate is instead converted to lactate because of the presence of the enzyme LDHA. Elevated LDHA keeps a process going that feeds the growth and survival of the tumor and also promotes the migration of the cancer cells throughout the body. It is suspected that if LDHA can be targeted, the growth of the cancer cells may be slowed. Researchers believe that treatments that impact LDHA may be important in future therapies.
In this study, led by Qing-Yi Lu of the Department of Medicine at UCLA, EGCG reduced the production of lactate in human pancreatic adenocarcinoma cells (MIA PaCa-2), as well as other metabolic processes such as anaerobic glycolysis, consumption of glucose and the glycolytic rate. It was assessed that the treatment “significantly modifies the cancer metabolic phenotype.”
The National Institute of Health reports being involved with five current trials related to prostate cancer and green tea extracts including studies on early stage prostate cancer, men having radical prostatectomies, and patients with low-risk cancers.
Source: Metabolic consequences of LDHA inhibition by epigallocatechin gallate and oxamate in MIA PaCa-2 pancreatic cancer cells, Metabolomics, Lu, Qing-Yu; Lifeng Zhang, Jennifer K. Yee, Vay-Liang W. Go, and Wai-Nang Lee. Accepted for publication May 2014.